2017

Yotsumoto S, Muroi Y, Chiba T, Ohmura R, Yoneyama M, Magarisawa M, Dodo K, Terayama N, Sodeoka M, Aoyagi R, Arita M, Arakawa S, Shimizu S, Tanaka M. Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep 7; 16026, 2017. 

Wang D, Li Q, Yang Y, Hao S, Han X, Song J, Yin Y, Li X, Tanaka M, Qiu CH. Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22. Inflammation 40; 1191-203, 2017. 

Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa T, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H. Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum. Hepatology 65; 237-52, 2017. 

Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM. CD169(+) macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Sci Immunol 2; eaah5520, 2017. 

Li Q, Wang D, Hao S, Han X, Xia Y, Li X, Chen Y, Tanaka M, Qiu CH. CD169 Expressing Macrophage, a Key Subset in Mesenteric Lymph Nodes Promotes Mucosal Inflammation in Dextran Sulfate Sodium-Induced Colitis. Front Immunol 8; 669, 2017. 

Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y. CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. JCI Insight 2; 2017. 

Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S, Sohara E. Salt suppresses IFNgamma inducible chemokines through the IFNgamma-JAK1-STAT1 signaling pathway in proximal tubular cells. Sci Rep 7; 46580, 2017. 

2016

Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S.‘Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.’Scientific Reports. 2016 Aug 12;6:31266. doi: 10.1038/srep31266. 

Yoshida T, Tsujioka M, Honda S, Tanaka M, Shimizu S. Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF. Oncotarget. 2016 Jun 7;7(23):34420-9. doi: 10.18632/oncotarget.8883 

2015

Tanaka M, Nishitai G. Immune Regulation by Dead Cell Clearance.Curr Top Microbiol Immunol. 2015 Aug 18. 

Karasawa K, Asano K, Moriyama S, Ushiki M, Monya M, Iida M, Kuboki E, Yagita H, Uchida K, Nitta K, and Tanaka M. ‘Vascular-resident CD169-Positive Monocytes and macrophages Control Neutrophil Accumulation in the Kidney with Ischemia-reperfusion Injury.’ Journal of American Society of Nephrology. 26:896-906, 2015. doi: 10.1681/ASN.2014020195. 

Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S. ‘Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis.’ Arterioscler Thromb Vasc Biol. 35(6):1423-33, 2015. doi: 10.1161/ATVBAHA.114.304846. 

Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, Wakana Y, Asano K, Tanaka M, Okuzaki D, Yamamoto A, Tani K, Tagaya M. ‘γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.’ J Cell Sci.128(15):2781-94, 2015. doi: 10.1242/jcs.158634. 

Asano K, Takahashi N, Ushiki M, Monya M, Aihara F, Kuboki E, Moriyama S, Iida M, Kitamura H, Qiu CH, Watanabe T, Tanaka M. ‘Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes.’ Nat Commun. 21;6:7802, 2015.doi: 10.1038/ncomms8802. 

2014

Yonekawa, A., Saijo, S., Hoshino, Y., Miyake, Y., Ishikawa, E., Suzukawa, M., Inoue, H., Tanaka, M., Yoneyama, M., Oh-Hora, M., Akashi, K., and Yamasaki, S. Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria. Immunity. 41(3):402-13.2014 

Taguchi K, Okada A, Kitamura H, Yasui T, Naik T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K. Colony-Stimulating Factor-1 Signaling Suppresses Renal Crystal Formation. J Am Soc Nephrol. 25(8) : 1680-1697, 2014. Published online before print February 27, 2014, doi: 10.1681/ASN.2013060675 

Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, P. Lemos H, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha L,　Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. Proc Natl Acad Sci USA. 111(11):4215-4220, 2014.　doi: 10.1073/pnas.1320924111. Epub 2014 Mar 3. Proceedings of the National Academy of Sciences of the United States of America. 

2013

Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, Garcia-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M. Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes. Immunity, 38: 792-804, 2013. . doi: 10.1016/j.immuni.2013.04.004. 

Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169(+) macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med, 19: 429-436, 2013. 

2012

Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL. Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A, 109: 3909-3914, 2012. 

Mizukami S, Kajiwara C, Tanaka M, Kaisho T, Udono H. Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein. Cancer Sci, 103: 851-859, 2012. 

2011

Muppidi JR, Arnon TI, Bronevetsky Y, Veerapen N, Tanaka M, Besra GS, Cyster JG. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. J Exp Med, 208: 1941-1948, 2011. 

Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Lohning M, Hengel H, Pfeffer K, Tanaka M, Haussinger D, Recher M, Lang PA, Lang KS. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol, 13: 51-57, 2011. 

Chow A, Lucas D, Hidalgo A, Mendez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van Rooijen N, Tanaka M, Merad M, Frenette PS. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med, 208: 261-271, 2011. 

Asano K, Nabeyama A, Miyake Y, Qiu CH, Kurita A, Tomura M, Kanagawa O, Fujii S, Tanaka M. CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens. Immunity, 34: 85-95, 2011. 

2010

Tanaka M, Asano K, Qiu CH. Immune regulation by apoptotic cell clearance. Ann N Y Acad Sci, 1209: 37-42, 2010. 

Nabeyama A, Kurita A, Asano K, Miyake Y, Yasuda T, Miura I, Nishitai G, Arakawa S, Shimizu S, Wakana S, Yoshida H, Tanaka M. xCT deficiency accelerates chemically induced tumorigenesis. Proc Natl Acad Sci U S A, 107: 6436-6441, 2010. 

2009

Tomura M, Mori YS, Watanabe R, Tanaka M, Miyawaki A, Kanagawa O. Time-lapse observation of cellular function with fluorescent probe reveals novel CTL-target cell interactions. Int Immunol, 21: 1145-1150, 2009. 

Qiu CH, Miyake Y, Kaise H, Kitamura H, Ohara O, Tanaka M. Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol, 182: 4127-4136, 2009. 

2008

Tanaka M, Miyake Y, Asano K. Maintenance of self-tolerance by apoptotic cell clearance. Front Biosci, 13: 6043-6049, 2008. 

2007

Witasp E, Uthaisang W, Elenstrom-Magnusson C, Hanayama R, Tanaka M, Nagata S, Orrenius S, Fadeel B. Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells. Cell Death Differ, 14: 1063-1065, 2007. 

Tanaka M,Miyake Y. Apoptotic cell clearance and autoimmune disorder. Curr Med Chem, 14: 2892-2897, 2007. 

Miyake Y, Kaise H, Isono K, Koseki H, Kohno K, Tanaka M. Protective Role of Macrophages in Noninflammatory Lung Injury Caused by Selective Ablation of Alveolar Epithelial Type II Cells. J Immunol, 178: 5001-5009, 2007. 

Miyake Y, Asano K, Kaise H, Uemura M, Nakayama M, Tanaka M. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest 117: 2268-2278, 2007. 

Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Ishii Y, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita-Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, J OW, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino K, Setoguchi R, Tamura Y, Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, Ohara O. Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics, 23: 2934-2941, 2007. 

2006

Nakaya M, Tanaka M, Okabe Y, Hanayama R, Nagata S. Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages. J Biol Chem, 281: 8836-8842, 2006. 

2005

Tanaka M. Apoptotic cell clearance by phagocytes. International Congress Series 1285, 55-59, 2005.

2004

Miyasaka K, Hanayama R, Tanaka M, Nagata S. Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells. Eur J Immunol, 34: 1414-1422, 2004. 

Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, Nagata S. Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice. Science, 304: 1147-1150, 2004. 

Hanayama R, Tanaka M, Miwa K, Nagata S. Expression of Developmental Endothelial Locus-1 in a Subset of Macrophages for Engulfment of Apoptotic Cells. J Immunol, 172: 3876-3882, 2004. 

Asano K, Miwa M, Miwa K, Hanayama R, Nagase H, Nagata S, Tanaka M. Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med, 200: 459-467, 2004. 

2003

Tada K, Tanaka M, Hanayama R, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Tethering of Apoptotic Cells to Phagocytes through Binding of CD47 to Src Homology 2 Domain-Bearing Protein Tyrosine Phosphatase Substrate-1. J Immunol, 171: 5718-5726, 2003. 

Nagase H, Fukuyama H, Tanaka M, Kawane K, Nagata S. Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation. Cell Death Differ, 10: 142-143, 2003. 

2002

Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature, 417: 182-187, 2002. 

2001

Shudo K, Kinoshita K, Imamura R, Fan H, Hasumoto K, Tanaka M, Nagata S, Suda T. The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity. Eur J Immunol, 31: 2504-2511, 2001. 

Itai T, Tanaka M, Nagata S. Processing of tumor necrosis factor by the membrane-bound TNF-alpha- converting enzyme, but not its truncated soluble form. Eur J Biochem, 268: 2074-2082., 2001. 

2000

McIlroy D, Tanaka M, Sakahira H, Fukuyama H, Suzuki M, Yamamura K, Ohsawa Y, Uchiyama Y, Nagata S. An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev, 14: 549-558, 2000. 

1999

Tanaka M, Fuentes ME, Yamaguchi K, Durnin MH, Dalrymple SA, Hardy KL, Goeddel DV. Embryonic lethality, liver degeneration, and impaired NF-kappaB activation in IKK-beta-deficient mice. Immunity, 10: 421-429, 1999. 

Cao Z, Tanaka M, Regnier C, Rothe M, Yamit-hezi A, Woronicz JD, Fuentes ME, Durnin MH, Dalrymple SA, Goeddel DV. NF-kappa B activation by tumor necrosis factor and interleukin-1. Cold Spring Harb Symp Quant Biol, 64: 473-483, 1999. 

1998

Yagi T, Sugimoto A, Tanaka M, Nagata S, Yasuda S, Yagita H, Kuriyama T, Takemori T, Tsunetsugu-Yokota Y. Fas/FasL interaction is not involved in apoptosis of activated CD4+ T cells upon HIV-1 infection in vitro. J Acquir Immune Defic Syndr Hum Retrovirol, 18: 307-315, 1998. 

Toyozaki T, Hiroe M, Tanaka M, Nagata S, Ohwada H, Marumo F. Levels of soluble Fas ligand in myocarditis. Am J Cardiol, 82: 246-248, 1998. 

Tanaka M, Itai T, Adachi M, Nagata S. Downregulation of Fas ligand by shedding. Nat Med, 4: 31-36, 1998. 

Mizuki M, Ueda S, Tagawa S, Shibayama H, Nishimori Y, Shibano M, Asada H, Tanaka M, Nagata S, Koudera U, Suzuki K, Machii T, Ohsawa M, Aozasa K, Kitani T, Kanakura Y. Natural killer cell-derived large granular lymphocyte lymphoma of lung developed in a patient with hypersensitivity to mosquito bites and reactivated Epstein-Barr virus infection. Am J Hematol, 59: 309-315, 1998. 

Hashimoto H, Tanaka M, Suda T, Tomita T, Hayashida K, Takeuchi E, Kaneko M, Takano H, Nagata S, Ochi T. Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum, 41: 657-662, 1998. 

Adachi S, Ito H, Tamamori M, Tanaka M, Marumo F, Hiroe M. Skeletal and smooth muscle alpha-actin mRNA in endomyocardial biopsy samples of dilated cardiomyopathy patients. Life Sci, 63: 1779-1791, 1998. 

1997

Tanaka M, Suda T, Yatomi T, Nakamura N, Nagata S. Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes. J Immunol, 158: 2303-2309, 1997. 

Suda T, Hashimoto H, Tanaka M, Ochi T, Nagata S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med, 186: 2045-2050, 1997. 

Ertel W, Keel M, Stocker R, Imhof HG, Leist M, Steckholzer U, Tanaka M, Trentz O, Nagata S. Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury. J Neuroimmunol, 80: 93-96, 1997. 

Bahr GM, Capron A, Dewulf J, Nagata S, Tanaka M, Bourez JM, Mouton Y. Elevated serum level of Fas ligand correlates with the asymptomatic stage of human immunodeficiency virus infection. Blood, 90: 896-898, 1997. 

1996

Tanaka M, Suda T, Haze K, Nakamura N, Sato K, Kimura F, Motoyoshi K, Mizuki M, Tagawa S, Ohga S, Hatake K, Drummond AH, Nagata S. Fas ligand in human serum. Nat Med, 2: 317-322, 1996. 

Takeda K, Yu ZX, Nishikawa T, Tanaka M, Hosoda S, Ferrans VJ, Kasajima T. Apoptosis and DNA fragmentation in the bulbus cordis of the developing rat heart. J Mol Cell Cardiol, 28: 209-215, 1996. 

Takahashi T, Tanaka M, Ogasawara J, Suda T, Murakami H, Nagata S. Swapping between Fas and granulocyte colony-stimulating factor receptor. J Biol Chem, 271: 17555-17560, 1996. 

Suda T, Tanaka M, Miwa K, Nagata S. Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand. J Immunol, 157: 3918-3924, 1996. 

Sato K, Kimura F, Nakamura Y, Murakami H, Yoshida M, Tanaka M, Nagata S, Kanatani Y, Wakimoto N, Nagata N, Motoyoshi K. An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand. Br J Haematol, 94: 379-382, 1996. 

Ito H, Adachi S, Tamamori M, Fujisaki H, Tanaka M, Lin M, Akimoto H, Marumo F, Hiroe M. Mild hypoxia induces hypertrophy of cultured neonatal rat cardiomyocytes: a possible endogenous endothelin-1-mediated mechanism. J Mol Cell Cardiol, 28: 1271-1277, 1996. 

Estaquier J, Tanaka M, Suda T, Nagata S, Golstein P, Ameisen JC. Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists. Blood, 87: 4959-4966, 1996. 

Akimoto H, Ito H, Tanaka M, Adachi S, Hata M, Lin M, Fujisaki H, Marumo F, Hiroe M. Heparin and heparan sulfate block angiotensin II-induced hypertrophy in cultured neonatal rat cardiomyocytes. A possible role of intrinsic heparin-like molecules in regulation of cardiomyocyte hypertrophy. Circulation, 93: 810-816, 1996. 

1995

Tanaka M, Suda T, Takahashi T, Nagata S. Expression of the functional soluble form of human fas ligand in activated lymphocytes. Embo J, 14: 1129-1135, 1995. 

Tanaka M, Hiroe M, Ito H, Nishikawa T, Adachi S, Aonuma K, Marumo F. Differential localization of atrial natriuretic peptide and skeletal alpha-actin messenger RNAs in left ventricular myocytes of patients with dilated cardiomyopathy. J Am Coll Cardiol, 26: 85-92, 1995. 

Fujisaki H, Ito H, Hirata Y, Tanaka M, Hata M, Lin M, Adachi S, Akimoto H, Marumo F, Hiroe M. Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression. J Clin Invest, 96: 1059-1065, 1995. 

Adachi S, Ito H, Ohta Y, Tanaka M, Ishiyama S, Nagata M, Toyozaki T, Hirata Y, Marumo F, Hiroe M. Distribution of mRNAs for natriuretic peptides in RV hypertrophy after pulmonary arterial banding. Am J Physiol, 268: H162-169, 1995. 

1994

Tanaka M, Ito H, Adachi S, Akimoto H, Nishikawa T, Kasajima T, Marumo F, Hiroe M. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res, 75: 426-433, 1994. 

Tanaka M, Hiroe M, Nishikawa T, Sato T, Marumo F. Cellular localization and structural characterization of natriuretic peptide-expressing ventricular myocytes from patients with dilated cardiomyopathy. J Histochem Cytochem, 42: 1207-1214, 1994. 

Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S. Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol, 6: 1567-1574, 1994. 

Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76: 969-976, 1994. 

Adachi S, Ito H, Akimoto H, Tanaka M, Fujisaki H, Marumo F, Hiroe M. Insulin-like growth factor-II induces hypertrophy with increased expression of muscle specific genes in cultured rat cardiomyocytes. J Mol Cell Cardiol, 26: 789-795, 1994. 

1993

Kawai M, Nishikawa T, Tanaka M, Ando A, Kasajima T, Higa T, Tanikawa T, Kagawa M, Momma K. An autopsied case of Williams syndrome complicated by moyamoya disease. Acta Paediatr Jpn, 35: 63-67, 1993. 

Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Murumo F, Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest, 92: 398-403, 1993. 

著書

Tanaka M, Nishitai G. Immune Regulation by Dead Cell Clearance. Curr Top Microbiol Immunol 403; 171-83, 2017.

Nagata S, Tanaka M. Programmed cell death and the immune system. Nat Rev Immunol 17; 333-40, 2017.

Kenichi Asano and Masato Tanaka‘Development of Sentinel-Cell Targeted Therapy for Inflammatory Bowel Diseases’Chronic Inflammation, Chapter 46, pp.617-626 DOI: 10.1007/978-4-431-56068-5_46

Nagata S, Tanaka M. Programmed cell death and the immune system. Nat Rev Immunol. 2017 May;17(5):333-340. doi: 10.1038/nri.2016.153. Epub 2017 Feb 6. Review.

邦文総説

浅野　謙一、田中　正人「死細胞貪食マクロファージ」 実験医学増刊Vol.34-No.7 2016, pp.1089-1094

西躰　元,　田中　正人「死細胞貪食マクロファージ」臨床免疫・アレルギー科　63:431-435(2015)

浅野　謙一、唐澤　一徳、田中　正人「CD169発現常在マクロファージによる組織恒常性維持と免疫制御」細胞工学　33:1261-1266(2014)

浅野　謙一、田中　正人「CD169陽性マクロファージの免疫制御機能」感染・炎症・免疫　41:26-34(2011)

浅野　謙一、田中　正人「死細胞の貪食異常と自己免疫疾患」実験医学26: 3019-3024(2008)

浅野　謙一、田中　正人「食細胞によるアポトーシス細胞の貪食異常と、自己免疫疾患」Molecular Medicine 41: 171-177(2005)

2023

Hiranuma R, Sato R, Yamaguchi K, Nakamizo S, Asano K, Shibata T, Fukui R, Furukawa Y, Kabashima K, Miyake K. Aberrant monocytopoiesis drives granuloma development in sarcoidosis. Int Immunol. 2023 Dec 26. doi: 10.1093/intimm/dxad054.

Asano K, Kikuchi K, Takehara M, Ogasawara M, Yoshioka Y, Ohnishi K, Iwata A, Shimizu S, Tanaka M. Identification of small compounds that inhibit multiple myeloma proliferation by targeting c-Maf transcriptional activity. Biochem Biophys Res Commun. 2023 Dec 3;684:149135. doi: 10.1016/j.bbrc.2023.149135.

Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Rep. 2023 Feb 28;42(3):112165. doi: 10.1016/j.celrep.2023.112165.

2022

Chihiro Kurematsu, Masato Sawada, Masaki Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, Mami Matsumoto, Hisashi Oishi, Hiroyuki Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, Truc Quynh Thai, Shinichi Kohsaka, Nobuhiko Ohno, Maki K Yamada, Masato Asai, Masahiro Sokabe, Junichi Nabekura, Kenichi Asano, Masato Tanaka, Kazunobu Sawamoto. Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine. The Journal of experimental medicine 219(4) 2022年4月4日

Abdouramane Camara, Alice C Lavanant, Jun Abe, Henri Lee Desforges, Yannick O Alexandre, Erika Girardi, Zinaida Igamberdieva, Kenichi Asano, Masato Tanaka, Thomas Hehlgans, Klaus Pfeffer, Sébastien Pfeffer, Scott N Mueller, Jens V Stein, Christopher G Mueller. CD169+ macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling. Proceedings of the National Academy of Sciences of the United States of America 119(3)

Xiaojia Song, Na Li, Yuan Liu, Zehua Wang, Tixiao Wang, Siyu Tan, Chunyang Li, Chunhong Qiu, Lifen Gao, Kenichi Asano, Masato Tanaka, Xiaohong Liang, Xinyong Liu, Chunhong Ma. CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Translational oncology 15(1)

2021

Fumika Honda, Hiroto Tsuboi, Yuko Ono, Saori Abe, Hiroyuki Takahashi, Kiyoaki Ito, Kazunori Yamada, Mitsuhiro Kawano, Yuya Kondo, Kenichi Asano, Masato Tanaka, Marie Malissen, Bernard Malissen, Isao Matsumoto, Takayuki Sumida. Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis. Arthritis research & therapy 23(1) 214-214

Sarah-Kim Friedrich, Rosa Schmitz, Michael Bergerhausen, Judith Lang, Vikas Duhan, Cornelia Hardt, Matthias Tenbusch, Marco Prinz, Kenichi Asano, Hilal Bhat, Thamer A Hamdan, Philipp Alexander Lang, Karl Sebastian Lang. Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation. Pathogens (Basel, Switzerland) 10(5)

Naohiro Takahashi, Hiroaki Kikuchi, Ayaka Usui, Taisuke Furusho, Takuya Fujimaru, Tamami Fujiki, Tomoki Yanagi, Yoshiaki Matsuura, Kenichi Asano, Kouhei Yamamoto, Fumiaki Ando, Koichiro Susa, Shintaro Mandai, Takayasu Mori, Tatemitsu Rai, Shinichi Uchida, Makoto Arita, Eisei Sohara. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney. Clinical and experimental nephrology 25(5)

Kei Ogawa, Kenichi Asano, Satoshi Yotsumoto, Tsuyoshi Yamane, Makoto Arita, Yoshihiro Hayashi, Hironori Harada, Chieko Makino-Okamura, Hidehiro Fukuyama, Kenji Kondo, Tatsuya Yamasoba, Masato Tanaka. Frontline Science: Conversion of neutrophils into atypical Ly6G+ SiglecF+ immune cells with neurosupportive potential in olfactory neuroepithelium. Journal of leukocyte biology 109(3) 481-496

Takumi Shibuya, Asami Kamiyama, Hirotaka Sawada, Kenta Kikuchi, Mayu Maruyama, Rie Sawado, Naoki Ikeda, Kenichi Asano, Daisuke Kurotaki, Tomohiko Tamura, Atsuko Yoneda, Keisuke Imada, Takashi Satoh, Shizuo Akira, Masato Tanaka, Satoshi Yotsumoto. Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor. Frontiers in immunology 12 663115-663115

2020

Yohei Arai, Kenichi Asano, Shintaro Mandai, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Naohiro Nomura, Tatemitsu Rai, Masato Tanaka, Shinichi Uchida, Eisei Sohara. WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages. Biochemical and biophysical research communications 533(4) 1290-1297

Yoshimi Uchida, Gen Nishitai, Kenta Kikuchi, Takumi Shibuya, Kenichi Asano, Masato Tanaka. CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice. Biochemistry and biophysics reports 23 100791-100791

Sebastian G Utz, Peter See, Wiebke Mildenberger, Morgane Sonia Thion, Aymeric Silvin, Mirjam Lutz, Florian Ingelfinger, Nirmala Arul Rayan, Iva Lelios, Anne Buttgereit, Kenichi Asano, Shyam Prabhakar, Sonia Garel, Burkhard Becher, Florent Ginhoux, Melanie Greter. Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development. Cell 181(3) 557-573

Mio Maeta, Naoya Miura, Hiroki Tanaka, Takashi Nakamura, Ryo Kawanishi, Yoshifumi Nishikawa, Kenichi Asano, Masato Tanaka, Shinya Tamagawa, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Hideyoshi Harashima, Hidetaka Akita. Vitamin E Scaffolds of pH-Responsive Lipid Nanoparticles as DNA Vaccines in Cancer and Protozoan Infection. Molecular pharmaceutics 17(4) 1237-1247

Sarah-Kim Friedrich, Rosa Schmitz, Michael Bergerhausen, Judith Lang, Lamin B Cham, Vikas Duhan, Dieter Häussinger, Cornelia Hardt, Marylyn Addo, Marco Prinz, Kenichi Asano, Philipp Alexander Lang, Karl Sebastian Lang. Usp18 Expression in CD169+ Macrophages is Important for Strong Immune Response after Vaccination with VSV-EBOV. Vaccines 8(1)

2019

Takuya Miyagawa, Kana Hasegawa, Yoko Aoki, Takuya Watanabe, Yuka Otagiri, Kohei Arasaki, Yuichi Wakana, Kenichi Asano, Masato Tanaka, Hideki Yamaguchi, Mitsuo Tagaya, Hiroki Inoue. MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane. The Journal of cell biology 218(10) 3355-3371

Kosuke Dodo, Erika Kuboki, Tadashi Shimizu, Ryu Imamura, Megumi Magarisawa, Masahiro Takahashi, Takuto Tokuhiro, Satoshi Yotsumoto, Kenichi Asano, Shuhei Nakao, Naoki Terayama, Takashi Suda, Masato Tanaka, Mikiko Sodeoka. Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis. ACS medicinal chemistry letters 10(9) 1272-1278

Abdouramane Camara, Olga G Cordeiro, Farouk Alloush, Janina Sponsel, Mélanie Chypre, Lucas Onder, Kenichi Asano, Masato Tanaka, Hideo Yagita, Burkhard Ludewig, Vincent Flacher, Christopher G Mueller. Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity 50(6) 1467-1481

Hiroto Takeya, Koji Ohnishi, Takuya Shiota, Yoichi Saito, Yukio Fujiwara, Taisuke Yagi, Yuki Kiyozumi, Yoshifumi Baba, Naoya Yoshida, Kenichi Asano, Masato Tanaka, Hideo Baba, Yoshihiro Komohara. Maf expression in human macrophages and lymph node sinus macrophages in patients with esophageal cancer. Journal of clinical and experimental hematopathology 59(3) 112-118

2018

Kikuchi K, Iida M, Ikeda N, Moriyama S, Hamada M, Takahashi S, Kitamura H, Watanabe T, Hasegawa Y, Hase K, Fukuhara T, Sato H, Kobayashi EH, Suzuki T, Yamamoto M, Tanaka M, Asano K. Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation. J Immunol 201; 635-51, 2018. 

Ikeda N, Asano K, Kikuchi K, Uchida Y, Ikegami H, Takagi R, Yotsumoto S, Shibuya T, Makino-Okamura C, Fukuyama H, Watanabe T, Ohmuraya M, Araki K, Nishitai G, Tanaka M. Emergence of immunoregulatory Ym1(+)Ly6C(hi) monocytes during recovery phase of tissue injury. Sci Immunol 3; 2018.  Published Paper

Deguchi Y, Nishina T, Asano K, Ohmuraya M, Nakagawa Y, Nakagata N, Sakuma T, Yamamoto T, Araki K, Mikami T, Tanaka M, Nakano H. Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice. Biochem Biophys Res Commun 505; 453-9, 2018. 

2017

Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y. CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. JCI Insight 2; 2017. 

Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S, Sohara E. Salt suppresses IFNgamma inducible chemokines through the IFNgamma-JAK1-STAT1 signaling pathway in proximal tubular cells. Sci Rep 7; 46580, 2017.

2016

Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S.‘Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.’Scientific Reports. 2016 Aug 12;6:31266. doi: 10.1038/srep31266. 

2015

Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S. ‘Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis.’ Arterioscler Thromb Vasc Biol. 35(6):1423-33, 2015. doi: 10.1161/ATVBAHA.114.304846 

Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, Wakana Y, Asano K, Tanaka M, Okuzaki D, Yamamoto A, Tani K, Tagaya M. ‘γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.’ J Cell Sci. 128(15):2781-94, 2015. doi: 10.1242/jcs.158634. 

Asano K, Takahashi N, Ushiki M, Monya M, Aihara F, Kuboki E, Moriyama S, Iida M, Kitamura H, Qiu CH, Watanabe T, Tanaka M. ‘Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes.’ Nat Commun. 21;6:7802, 2015.doi: 10.1038/ncomms8802. 

Karasawa K., Asano K., Moriyama S., Ushiki M., Monya M., Iida M., Kuboki E., Yagita H., Uchida K., Nitta K., and Tanaka M.‘Vascular-resident CD169-Positive Monocytes and macrophages Control Neutrophil Accumulation in the Kidney with Ischemia-reperfusion Injury’Journal of American Society of Nephrology 26:896-906 (2015) 

2014

Taguchi K., Okada A., Kitamura H., Yasui T., Naiki T., Hamamoto S., Ando R., Mizuno K., Kawai N., Tozawa K., Asano K., Tanaka M., Miyoshi I., and Kohri K.‘Colony-Stimulating Factor-1 Signaling Suppresses Renal Crystal Formation’Journal of American Society of Nephrology 25:1680-1697 (2014) 

2011

Asano K., Nabeyama A., Miyake Y., Qiu C.H., Kurita A., Tomura M., Kanagawa O., Fujii S., Tanaka M.‘CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens.’Immunity 34: 85-95 (2011). 

2010

Tanaka M, Asano K, Qiu CH.‘Immune regulation by apoptotic cell clearance.’Annals of New York Academy of Sciences 1209: 37-42 (2010). 

Nabeyama A., Kurita A., Asano K., Miyake Y., Yasuda T., Miura I., Nishitai G., Arakawa S., Shimizu S., Wakana S., Yoshida H., Tanaka M.‘xCT deficiency accelerates chemically induced tumorigenesis.’Proceedings of the National Academy of Sciences of the United States of America 107:6436-6441 (2010). 

2009

Okamoto Y., Christen T., Shimizu K., Asano K., Kihara S., Mitchell RN, Libby P.‘Adiponectin inhibits allograft rejection in murine cardiac transplantation.’Transplantation 88: 879-883 (2009). 

2008

Tsuboi N*., Asano K.*, Lauterbach M., Mayadas TN. (* Equally contributed）‘Human neutrophil Fc receptors initiate and play selective roles in antibody- mediated inflammatory diseases.’Immunity 28: 833- 846 (2008). 

Tanaka M., Miyake Y., Asano, K.‘Maintenance of self- tolerance by apoptotic cell clearance.’Frontiers in Bioscience 13: 6043- 6049 (2008). 

Utomo A., Hirahashi J., Mekala D., Asano, K., Glogauer M., Cullere X., Mayadas TN.‘Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3- dependent injury.’Journal of Immunology 180: 6279- 6287 (2008). 

Shimizu K., Libby P., Shubiki R., Sakuma M., Wang Y., Asano K., Mitchell RN., Simon DI.‘Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection.’Circulation 117: 1997-2008 (2008). 

Lauterbach M., O’Donnel P., Asano, K., Mayadas TN.‘Role of TNF priming and adhesion molecules in neutrophil recruitment to intravascular immune complexes.’Journal of Leukocyte Biology 83: 1423- 1430 (2008). 

2007

Miyake Y.*, Asano K.*, Kaise H., Uemura M., Nakayama M., Tanaka M. (*Equallycontributed）‘Critical role of macrophages in the marginal zone in immune suppression to apoptotic cell-associated antigens.’The Journal of Clinical Investigation 117: 2268- 2278 (2007).  

2004

Asano K. Miwa M., Miwa K., Hanayama R., Nagase H., Nagata S., Tanaka, M.‘Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice.’ Journal of Experimental Medicine 200: 459- 467 (2004). 

著書

Kenichi Asano and Masato Tanaka‘Development of Sentinel-Cell Targeted Therapy for Inflammatory Bowel Diseases’Chronic Inflammation, Chapter 46, pp.617-626 DOI: 10.1007/978-4-431-56068-5_46

邦文総説

浅野　謙一、田中　正人「死細胞貪食マクロファージ」 実験医学増刊Vol.34-No.7 2016, pp.1089-1094

浅野　謙一、唐澤　一徳、田中　正人「CD169発現常在マクロファージによる組織恒常性維持と免疫制御」細胞工学　33:1261-1266(2014)

浅野　謙一、田中　正人「CD169陽性マクロファージの免疫制御機能」感染・炎症・免疫　41:26-34(2011)

浅野　謙一、田中　正人「死細胞の貪食異常と自己免疫疾患」実験医学26: 3019-3024(2008)

浅野　謙一、田中　正人「食細胞によるアポトーシス細胞の貪食異常と、自己免疫疾患」Molecular Medicine 41: 171-177(2005)

主要特許

「炎症性腸疾患を抑制する抗体および該抗体を含む医薬組成物」　特許登録番号6947372

「免疫調節作用を有する単球細胞及びその使用方法」出願番号2018-097457

「がん転移抑制のための医薬組成物」出願番号2021-126801

「がんの予防および／または治療のための医薬組成物」出願番号2021-140333

「多発性骨髄腫の処置のための医薬組成物」出願番号2021-192959

2017

Yotsumoto S, Muroi Y, Chiba T, Ohmura R, Yoneyama M, Magarisawa M, Dodo K, Terayama N, Sodeoka M, Aoyagi R, Arita M, Arakawa S, Shimizu S, Tanaka M. Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep 7; 16026, 2017. 

Kawamura S, Onai N, Miya F, Sato T, Tsunoda T, Kurabayashi K, Yotsumoto S, Kuroda S, Takenaka K, Akashi K, Ohteki T.Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. Immunity. 2017 May 16;46(5):835-848. 

2016以前

Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Müller W, Kurabayashi K, Hosoi-Amaike M., Takahashi N., Hirokawa M., Matsushima K., Sawada K. & Ohteki T. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity 39, p584-598. (2013). 

Sato T., Ikeda M., Yotsumoto S., Shimada Y., Higuchi T., Kobayashi H., Fukuda T., Ohashi T., Suda T. & Ohteki T. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood 121, p3267-3273. (2013). 

Yotsumoto S., Saegusa K. & Aramaki Y. Endosomal translocation of CpG-oligodeoxynucleotides inhibits DNA-PKcs-dependent IL-10 production in macrophages. J Immunol 180, p809-816 (2008). 

Saegusa K, Yotsumoto S., Kato S. & Aramaki Y. Phosphatidylinositol 3-kinase-mediated regulation of IL-10 and IL-12 production in macrophages stimulated with CpG oligodeoxynucleotide. Mol Immunol 44, p1323-1330. (2007). 

Yotsumoto S., Kakiuchi T. & Aramaki Y. Enhancement of IFN-gamma production for Th1-cell therapy using negatively charged liposomes containing phosphatidylserine. Vaccine 25, p5256-5262. (2007). 

Inoue J., Yotsumoto S., Sakamoto T., Tsuchiya S. & Aramaki Y. Changes in immune responses to mite antigen sensitized through barrier-disrupted skin with CpG-oligodeoxynucleotide in mice. Biol Pharm Bull 29, p385-387 (2006). 

Yoshida T., Oide N., Sakamoto T., Yotsumoto S., Negishi Y., Tsuchiya S. & Aramaki Y. Induction of cancer cell-specific apoptosis by folate-labeled cationic liposomes. J Control Release 111, p325-332. (2006). 

Inoue J., Yotsumoto S., Sakamoto T., Tsuchiya S. & Aramaki Y. Changes in immune responses to antigen applied to tape-stripped skin with CpG-oligodeoxynucleotide in mice. J Control Release 108, p294-305. (2005). 

Inoue J., otsumoto S., Sakamoto T., Tsuchiya S. & Aramaki Y. Changes in immune responses to antigen applied to tape-stripped skin with CpG-oligodeoxynucleotide in NC/Nga mice. Pharm Res 22, p1627-1633. (2005). 

Yotsumoto S., Kakiuchi T. & Aramaki Y. Negatively charged phospholipids suppress IFN-gamma production in T cells. Biochem Biophys Res Commun 338, p1719-1725. (2005). 

Yotsumoto S., Aramaki Y., Kakiuchi T. & Tsuchiya S. Induction of antigen-dependent interleukin-12 production by negatively charged liposomes encapsulating antigens. Vaccine 22, 3503-3509. (2004). 

Aramaki Y., Yotsumoto S., Watanabe H. & Tsuchiya S. NADPH-oxidase may contribute to IL-12 production in macrophages stimulated with CpG phosphorothioate oligodeoxynucleotides. Biol Pharm Bull 25, p351-355. (2002). 

総説・著書

四元聡志, 田中正人. 好中球細胞外トラップの誘導機構とその生理的および病理的意義. 臨床免疫・アレルギー科. 70巻3号p301. (2018)

四元聡志, 樗木俊聡. IL-15. 朝倉書店, 桂義元, 河本 宏, 小安重夫, 山村一彦 (編) 免疫の事典. p61. (2011).

横山 晴子, 四元 聡志, 坂本 宜俊, 新槇幸彦, 山田安彦. カレントトピックス2005 注射剤調剤;　第1章 注射剤調剤の推進に向けて.月刊薬事 臨時増刊. 47巻4号p549. (2005).