Laboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Science

Member


  • Professor
    Masato Tanaka
    mtanaka(a)toyaku.ac.jp

  • Associate Professor
    Kenichi Asano
    asanok(a)toyaku.ac.jp

  • Assistant Professor
    Satoshi Yotsumoto
    yotumoto(a)toyaku.ac.jp

*To send e-mail, please change "(a)" to "@".

D3 Naoki Ikeda / Erika Kuboki
D2 Yoshimi Uchida
D1 Takumi Shibutani
M2 Tomoyo Odate / Kenta Kikuchi / Arisa Nakamura
Megumi Magarisawa / Tadatomo Muroi
M1 Remi Iwamoto / Rio Omura / Tatsuya Chiba
Wakako Taniuchi
Graduate research student 12 students enrolled
Visiting researcher Kazunori Karasawa
Assistant researcher Wakako Okawa
Secretary Masumi Kawana
Publication

Publication List Professor Masato Tanaka

  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • ~2009
  • book
  • review

2016

Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S.‘Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.’Scientific Reports. 2016 Aug 12;6:31266. doi: 10.1038/srep31266. 

Yoshida T, Tsujioka M, Honda S, Tanaka M, Shimizu S. Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF. Oncotarget. 2016 Jun 7;7(23):34420-9. doi: 10.18632/oncotarget.8883 

2015

Tanaka M, Nishitai G. Immune Regulation by Dead Cell Clearance.Curr Top Microbiol Immunol. 2015 Aug 18. 

Karasawa K, Asano K, Moriyama S, Ushiki M, Monya M, Iida M, Kuboki E, Yagita H, Uchida K, Nitta K, and Tanaka M. ‘Vascular-resident CD169-Positive Monocytes and macrophages Control Neutrophil Accumulation in the Kidney with Ischemia-reperfusion Injury.’ Journal of American Society of Nephrology. 26:896-906, 2015. doi: 10.1681/ASN.2014020195. 

Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S. ‘Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis.’ Arterioscler Thromb Vasc Biol. 35(6):1423-33, 2015. doi: 10.1161/ATVBAHA.114.304846. 

Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, Wakana Y, Asano K, Tanaka M, Okuzaki D, Yamamoto A, Tani K, Tagaya M. ‘γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.’ J Cell Sci.128(15):2781-94, 2015. doi: 10.1242/jcs.158634. 

Asano K, Takahashi N, Ushiki M, Monya M, Aihara F, Kuboki E, Moriyama S, Iida M, Kitamura H, Qiu CH, Watanabe T, Tanaka M. ‘Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes.’ Nat Commun. 21;6:7802, 2015.doi: 10.1038/ncomms8802. 

2014

Yonekawa, A., Saijo, S., Hoshino, Y., Miyake, Y., Ishikawa, E., Suzukawa, M., Inoue, H., Tanaka, M., Yoneyama, M., Oh-Hora, M., Akashi, K., and Yamasaki, S. Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria. Immunity. 41(3):402-13.2014 

Taguchi K, Okada A, Kitamura H, Yasui T, Naik T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K. Colony-Stimulating Factor-1 Signaling Suppresses Renal Crystal Formation. J Am Soc Nephrol. 25(8) : 1680-1697, 2014. Published online before print February 27, 2014, doi: 10.1681/ASN.2013060675 

Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, P. Lemos H, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha L, Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. Proc Natl Acad Sci USA. 111(11):4215-4220, 2014. doi: 10.1073/pnas.1320924111. Epub 2014 Mar 3. Proceedings of the National Academy of Sciences of the United States of America. 

2013

Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, Garcia-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M. Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes. Immunity, 38: 792-804, 2013. . doi: 10.1016/j.immuni.2013.04.004. 

Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169(+) macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med, 19: 429-436, 2013. 

2012

Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL. Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A, 109: 3909-3914, 2012. 

Mizukami S, Kajiwara C, Tanaka M, Kaisho T, Udono H. Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein. Cancer Sci, 103: 851-859, 2012. 

2011

Muppidi JR, Arnon TI, Bronevetsky Y, Veerapen N, Tanaka M, Besra GS, Cyster JG. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. J Exp Med, 208: 1941-1948, 2011. 

Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Lohning M, Hengel H, Pfeffer K, Tanaka M, Haussinger D, Recher M, Lang PA, Lang KS. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol, 13: 51-57, 2011. 

Chow A, Lucas D, Hidalgo A, Mendez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van Rooijen N, Tanaka M, Merad M, Frenette PS. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med, 208: 261-271, 2011. 

Asano K, Nabeyama A, Miyake Y, Qiu CH, Kurita A, Tomura M, Kanagawa O, Fujii S, Tanaka M. CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens. Immunity, 34: 85-95, 2011. 

2010

Tanaka M, Asano K, Qiu CH. Immune regulation by apoptotic cell clearance. Ann N Y Acad Sci, 1209: 37-42, 2010. 

Nabeyama A, Kurita A, Asano K, Miyake Y, Yasuda T, Miura I, Nishitai G, Arakawa S, Shimizu S, Wakana S, Yoshida H, Tanaka M. xCT deficiency accelerates chemically induced tumorigenesis. Proc Natl Acad Sci U S A, 107: 6436-6441, 2010. 

2009

Tomura M, Mori YS, Watanabe R, Tanaka M, Miyawaki A, Kanagawa O. Time-lapse observation of cellular function with fluorescent probe reveals novel CTL-target cell interactions. Int Immunol, 21: 1145-1150, 2009. 

Qiu CH, Miyake Y, Kaise H, Kitamura H, Ohara O, Tanaka M. Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol, 182: 4127-4136, 2009. 

2008

Tanaka M, Miyake Y, Asano K. Maintenance of self-tolerance by apoptotic cell clearance. Front Biosci, 13: 6043-6049, 2008. 

2007

Witasp E, Uthaisang W, Elenstrom-Magnusson C, Hanayama R, Tanaka M, Nagata S, Orrenius S, Fadeel B. Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells. Cell Death Differ, 14: 1063-1065, 2007. 

Tanaka M,Miyake Y. Apoptotic cell clearance and autoimmune disorder. Curr Med Chem, 14: 2892-2897, 2007. 

Miyake Y, Kaise H, Isono K, Koseki H, Kohno K, Tanaka M. Protective Role of Macrophages in Noninflammatory Lung Injury Caused by Selective Ablation of Alveolar Epithelial Type II Cells. J Immunol, 178: 5001-5009, 2007. 

Miyake Y, Asano K, Kaise H, Uemura M, Nakayama M, Tanaka M. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest 117: 2268-2278, 2007. 

Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Ishii Y, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita-Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, J OW, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino K, Setoguchi R, Tamura Y, Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, Ohara O. Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics, 23: 2934-2941, 2007. 

2006

Nakaya M, Tanaka M, Okabe Y, Hanayama R, Nagata S. Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages. J Biol Chem, 281: 8836-8842, 2006. 

2005

Tanaka M. Apoptotic cell clearance by phagocytes. International Congress Series 1285, 55-59, 2005.

2004

Miyasaka K, Hanayama R, Tanaka M, Nagata S. Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells. Eur J Immunol, 34: 1414-1422, 2004. 

Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, Nagata S. Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice. Science, 304: 1147-1150, 2004. 

Hanayama R, Tanaka M, Miwa K, Nagata S. Expression of Developmental Endothelial Locus-1 in a Subset of Macrophages for Engulfment of Apoptotic Cells. J Immunol, 172: 3876-3882, 2004. 

Asano K, Miwa M, Miwa K, Hanayama R, Nagase H, Nagata S, Tanaka M. Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med, 200: 459-467, 2004. 

2003

Tada K, Tanaka M, Hanayama R, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Tethering of Apoptotic Cells to Phagocytes through Binding of CD47 to Src Homology 2 Domain-Bearing Protein Tyrosine Phosphatase Substrate-1. J Immunol, 171: 5718-5726, 2003. 

Nagase H, Fukuyama H, Tanaka M, Kawane K, Nagata S. Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation. Cell Death Differ, 10: 142-143, 2003. 

2002

Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature, 417: 182-187, 2002. 

2001

Shudo K, Kinoshita K, Imamura R, Fan H, Hasumoto K, Tanaka M, Nagata S, Suda T. The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity. Eur J Immunol, 31: 2504-2511, 2001. 

Itai T, Tanaka M, Nagata S. Processing of tumor necrosis factor by the membrane-bound TNF-alpha- converting enzyme, but not its truncated soluble form. Eur J Biochem, 268: 2074-2082., 2001. 

2000

McIlroy D, Tanaka M, Sakahira H, Fukuyama H, Suzuki M, Yamamura K, Ohsawa Y, Uchiyama Y, Nagata S. An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev, 14: 549-558, 2000. 

1999

Tanaka M, Fuentes ME, Yamaguchi K, Durnin MH, Dalrymple SA, Hardy KL, Goeddel DV. Embryonic lethality, liver degeneration, and impaired NF-kappaB activation in IKK-beta-deficient mice. Immunity, 10: 421-429, 1999. 

Cao Z, Tanaka M, Regnier C, Rothe M, Yamit-hezi A, Woronicz JD, Fuentes ME, Durnin MH, Dalrymple SA, Goeddel DV. NF-kappa B activation by tumor necrosis factor and interleukin-1. Cold Spring Harb Symp Quant Biol, 64: 473-483, 1999. 

1998

Yagi T, Sugimoto A, Tanaka M, Nagata S, Yasuda S, Yagita H, Kuriyama T, Takemori T, Tsunetsugu-Yokota Y. Fas/FasL interaction is not involved in apoptosis of activated CD4+ T cells upon HIV-1 infection in vitro. J Acquir Immune Defic Syndr Hum Retrovirol, 18: 307-315, 1998. 

Toyozaki T, Hiroe M, Tanaka M, Nagata S, Ohwada H, Marumo F. Levels of soluble Fas ligand in myocarditis. Am J Cardiol, 82: 246-248, 1998. 

Tanaka M, Itai T, Adachi M, Nagata S. Downregulation of Fas ligand by shedding. Nat Med, 4: 31-36, 1998. 

Mizuki M, Ueda S, Tagawa S, Shibayama H, Nishimori Y, Shibano M, Asada H, Tanaka M, Nagata S, Koudera U, Suzuki K, Machii T, Ohsawa M, Aozasa K, Kitani T, Kanakura Y. Natural killer cell-derived large granular lymphocyte lymphoma of lung developed in a patient with hypersensitivity to mosquito bites and reactivated Epstein-Barr virus infection. Am J Hematol, 59: 309-315, 1998. 

Hashimoto H, Tanaka M, Suda T, Tomita T, Hayashida K, Takeuchi E, Kaneko M, Takano H, Nagata S, Ochi T. Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum, 41: 657-662, 1998. 

Adachi S, Ito H, Tamamori M, Tanaka M, Marumo F, Hiroe M. Skeletal and smooth muscle alpha-actin mRNA in endomyocardial biopsy samples of dilated cardiomyopathy patients. Life Sci, 63: 1779-1791, 1998. 

1997

Tanaka M, Suda T, Yatomi T, Nakamura N, Nagata S. Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes. J Immunol, 158: 2303-2309, 1997. 

Suda T, Hashimoto H, Tanaka M, Ochi T, Nagata S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med, 186: 2045-2050, 1997. 

Ertel W, Keel M, Stocker R, Imhof HG, Leist M, Steckholzer U, Tanaka M, Trentz O, Nagata S. Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury. J Neuroimmunol, 80: 93-96, 1997. 

Bahr GM, Capron A, Dewulf J, Nagata S, Tanaka M, Bourez JM, Mouton Y. Elevated serum level of Fas ligand correlates with the asymptomatic stage of human immunodeficiency virus infection. Blood, 90: 896-898, 1997. 

1996

Tanaka M, Suda T, Haze K, Nakamura N, Sato K, Kimura F, Motoyoshi K, Mizuki M, Tagawa S, Ohga S, Hatake K, Drummond AH, Nagata S. Fas ligand in human serum. Nat Med, 2: 317-322, 1996. 

Takeda K, Yu ZX, Nishikawa T, Tanaka M, Hosoda S, Ferrans VJ, Kasajima T. Apoptosis and DNA fragmentation in the bulbus cordis of the developing rat heart. J Mol Cell Cardiol, 28: 209-215, 1996. 

Takahashi T, Tanaka M, Ogasawara J, Suda T, Murakami H, Nagata S. Swapping between Fas and granulocyte colony-stimulating factor receptor. J Biol Chem, 271: 17555-17560, 1996. 

Suda T, Tanaka M, Miwa K, Nagata S. Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand. J Immunol, 157: 3918-3924, 1996. 

Sato K, Kimura F, Nakamura Y, Murakami H, Yoshida M, Tanaka M, Nagata S, Kanatani Y, Wakimoto N, Nagata N, Motoyoshi K. An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand. Br J Haematol, 94: 379-382, 1996. 

Ito H, Adachi S, Tamamori M, Fujisaki H, Tanaka M, Lin M, Akimoto H, Marumo F, Hiroe M. Mild hypoxia induces hypertrophy of cultured neonatal rat cardiomyocytes: a possible endogenous endothelin-1-mediated mechanism. J Mol Cell Cardiol, 28: 1271-1277, 1996. 

Estaquier J, Tanaka M, Suda T, Nagata S, Golstein P, Ameisen JC. Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists. Blood, 87: 4959-4966, 1996. 

Akimoto H, Ito H, Tanaka M, Adachi S, Hata M, Lin M, Fujisaki H, Marumo F, Hiroe M. Heparin and heparan sulfate block angiotensin II-induced hypertrophy in cultured neonatal rat cardiomyocytes. A possible role of intrinsic heparin-like molecules in regulation of cardiomyocyte hypertrophy. Circulation, 93: 810-816, 1996. 

1995

Tanaka M, Suda T, Takahashi T, Nagata S. Expression of the functional soluble form of human fas ligand in activated lymphocytes. Embo J, 14: 1129-1135, 1995. 

Tanaka M, Hiroe M, Ito H, Nishikawa T, Adachi S, Aonuma K, Marumo F. Differential localization of atrial natriuretic peptide and skeletal alpha-actin messenger RNAs in left ventricular myocytes of patients with dilated cardiomyopathy. J Am Coll Cardiol, 26: 85-92, 1995. 

Fujisaki H, Ito H, Hirata Y, Tanaka M, Hata M, Lin M, Adachi S, Akimoto H, Marumo F, Hiroe M. Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression. J Clin Invest, 96: 1059-1065, 1995. 

Adachi S, Ito H, Ohta Y, Tanaka M, Ishiyama S, Nagata M, Toyozaki T, Hirata Y, Marumo F, Hiroe M. Distribution of mRNAs for natriuretic peptides in RV hypertrophy after pulmonary arterial banding. Am J Physiol, 268: H162-169, 1995. 

1994

Tanaka M, Ito H, Adachi S, Akimoto H, Nishikawa T, Kasajima T, Marumo F, Hiroe M. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res, 75: 426-433, 1994. 

Tanaka M, Hiroe M, Nishikawa T, Sato T, Marumo F. Cellular localization and structural characterization of natriuretic peptide-expressing ventricular myocytes from patients with dilated cardiomyopathy. J Histochem Cytochem, 42: 1207-1214, 1994. 

Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S. Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol, 6: 1567-1574, 1994. 

Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76: 969-976, 1994. 

Adachi S, Ito H, Akimoto H, Tanaka M, Fujisaki H, Marumo F, Hiroe M. Insulin-like growth factor-II induces hypertrophy with increased expression of muscle specific genes in cultured rat cardiomyocytes. J Mol Cell Cardiol, 26: 789-795, 1994. 

1993

Kawai M, Nishikawa T, Tanaka M, Ando A, Kasajima T, Higa T, Tanikawa T, Kagawa M, Momma K. An autopsied case of Williams syndrome complicated by moyamoya disease. Acta Paediatr Jpn, 35: 63-67, 1993. 

Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Murumo F, Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest, 92: 398-403, 1993. 

book

Kenichi Asano and Masato Tanaka‘Development of Sentinel-Cell Targeted Therapy for Inflammatory Bowel Diseases’Chronic Inflammation, Chapter 46, pp.617-626 DOI: 10.1007/978-4-431-56068-5_46

Nagata S, Tanaka M. Programmed cell death and the immune system. Nat Rev Immunol. 2017 May;17(5):333-340. doi: 10.1038/nri.2016.153. Epub 2017 Feb 6. Review.

review

Asano K, Tanaka M“Engulfment abnormity of apoptotic cell by phagocytes, and autoimmune disease”Molecular Medicine 41: 171-177(2005)

Asano K, Tanaka M“Engulfment abnormity in dying cell, and autoimmune disease”26: 3019-3024(2008)

Asano K, Tanaka M“CD169-positive macrophages immune regulation mechanism Infection inflammatory immunity” 41:26-34(2011)

Asano K, karasawa K, Tanaka M“Immune Regulation by Tissue Resident CD169-positive Macrophages”33:1261-1266(2014)

西躰 元, 田中 正人「死細胞貪食マクロファージ」臨床免疫・アレルギー科 63:431-435(2015)

浅野 謙一、田中 正人「死細胞貪食マクロファージ」 実験医学増刊Vol.34-No.7 2016, pp.1089-1094

Publication List Associate Professor Kenichi Asano

  • 2016
  • 2015
  • 2014
  • 2011
  • 2010
  • 2009
  • 2008
  • ~2007
  • book
  • review
  • main patent

2016

Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S.‘Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.’Scientific Reports. 2016 Aug 12;6:31266. doi: 10.1038/srep31266. 

2015

Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S. ‘Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis.’ Arterioscler Thromb Vasc Biol. 35(6):1423-33, 2015. doi: 10.1161/ATVBAHA.114.304846 

Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, Wakana Y, Asano K, Tanaka M, Okuzaki D, Yamamoto A, Tani K, Tagaya M. ‘γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.’ J Cell Sci. 128(15):2781-94, 2015. doi: 10.1242/jcs.158634. 

Asano K, Takahashi N, Ushiki M, Monya M, Aihara F, Kuboki E, Moriyama S, Iida M, Kitamura H, Qiu CH, Watanabe T, Tanaka M. ‘Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes.’ Nat Commun. 21;6:7802, 2015.doi: 10.1038/ncomms8802. 

Karasawa K., Asano K., Moriyama S., Ushiki M., Monya M., Iida M., Kuboki E., Yagita H., Uchida K., Nitta K., and Tanaka M.‘Vascular-resident CD169-Positive Monocytes and macrophages Control Neutrophil Accumulation in the Kidney with Ischemia-reperfusion Injury’Journal of American Society of Nephrology 26:896-906 (2015) 

2014

Taguchi K., Okada A., Kitamura H., Yasui T., Naiki T., Hamamoto S., Ando R., Mizuno K., Kawai N., Tozawa K., Asano K., Tanaka M., Miyoshi I., and Kohri K.‘Colony-Stimulating Factor-1 Signaling Suppresses Renal Crystal Formation’Journal of American Society of Nephrology 25:1680-1697 (2014) 

2011

Asano K., Nabeyama A., Miyake Y., Qiu C.H., Kurita A., Tomura M., Kanagawa O., Fujii S., Tanaka M.‘CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens.’Immunity 34: 85-95 (2011). 

2010

Tanaka M, Asano K, Qiu CH.‘Immune regulation by apoptotic cell clearance.’Annals of New York Academy of Sciences 1209: 37-42 (2010). 

Nabeyama A., Kurita A., Asano K., Miyake Y., Yasuda T., Miura I., Nishitai G., Arakawa S., Shimizu S., Wakana S., Yoshida H., Tanaka M.‘xCT deficiency accelerates chemically induced tumorigenesis.’Proceedings of the National Academy of Sciences of the United States of America 107:6436-6441 (2010). 

2009

Okamoto Y., Christen T., Shimizu K., Asano K., Kihara S., Mitchell RN, Libby P.‘Adiponectin inhibits allograft rejection in murine cardiac transplantation.’Transplantation 88: 879-883 (2009). 

2008

Tsuboi N*., Asano K.*, Lauterbach M., Mayadas TN. (* Equally contributed)‘Human neutrophil Fc receptors initiate and play selective roles in antibody- mediated inflammatory diseases.’Immunity 28: 833- 846 (2008). 

Tanaka M., Miyake Y., Asano, K.‘Maintenance of self- tolerance by apoptotic cell clearance.’Frontiers in Bioscience 13: 6043- 6049 (2008). 

Utomo A., Hirahashi J., Mekala D., Asano, K., Glogauer M., Cullere X., Mayadas TN.‘Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3- dependent injury.’Journal of Immunology 180: 6279- 6287 (2008). 

Shimizu K., Libby P., Shubiki R., Sakuma M., Wang Y., Asano K., Mitchell RN., Simon DI.‘Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection.’Circulation 117: 1997-2008 (2008). 

Lauterbach M., O’Donnel P., Asano, K., Mayadas TN.‘Role of TNF priming and adhesion molecules in neutrophil recruitment to intravascular immune complexes.’Journal of Leukocyte Biology 83: 1423- 1430 (2008). 

2007

Miyake Y.*, Asano K.*, Kaise H., Uemura M., Nakayama M., Tanaka M. (*Equallycontributed)‘Critical role of macrophages in the marginal zone in immune suppression to apoptotic cell-associated antigens.’The Journal of Clinical Investigation 117: 2268- 2278 (2007).  

2004

Asano K. Miwa M., Miwa K., Hanayama R., Nagase H., Nagata S., Tanaka, M.‘Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice.’ Journal of Experimental Medicine 200: 459- 467 (2004). 

book

Kenichi Asano and Masato Tanaka‘Development of Sentinel-Cell Targeted Therapy for Inflammatory Bowel Diseases’Chronic Inflammation, Chapter 46, pp.617-626 DOI: 10.1007/978-4-431-56068-5_46

review

Asano K, Tanaka M“Engulfment abnormity of apoptotic cell by phagocytes, and autoimmune disease”Molecular Medicine 41: 171-177(2005)

Asano K, Tanaka M“Engulfment abnormity in dying cell, and autoimmune disease”26: 3019-3024(2008)

Asano K, Tanaka M“CD169-positive macrophages immune regulation mechanism Infection inflammatory immunity” 41:26-34(2011)

Asano K, karasawa K, Tanaka M“Immune Regulation by Tissue Resident CD169-positive Macrophages”33:1261-1266(2014)

浅野 謙一、田中 正人「死細胞貪食マクロファージ」 実験医学増刊Vol.34-No.7 2016, pp.1089-1094

main patent

“Control of immune responses in use of apoptotic cells bound to antigen”application number 2006-286732 2006

「炎症性腸疾患を抑制する抗体および該抗体を含む医薬組成物」特願2015-106658